Alan Kay gave the following advice to Bret Victor once:
I think the trick with knowledge is to "acquire it, and forget all except the perfume" -- because it is noisy and sometimes drowns out one's own "brain voices". The perfume part is important because it will help find the knowledge again to help get to the destinations the inner urges pick. (Source)
It would seem that the challenge with knowledge is holding on just tight enough that if you need to grip harder, you can, but if you need to change hand grips, you can also do that as well.